Mechanimix
Virtual Showroom Contact

Crystallization Systems

Integrated solutions with jacketed reactor, low-shear HWM impeller and precise temperature ramp system for controlled nucleation and crystal growth. Runs in batch and continuous modes.

±0.5°C
Temperature Accuracy
1 – 3 m/s
Tip Speed Range
D50
Particle Size Control
Batch + Continuous
Process Mode
Crystallization system — jacketed reactor and low-shear HWM impeller
GENEL BAKIŞ

Mechanimix Approach to Crystallization Systems

In crystallization, product quality is measured by purity, crystal size distribution (CSD) and crystal form (polymorph), and these parameters are driven by the temperature profile, mixing intensity and supersaturation profile. Mechanimix crystallization systems let you reliably hit the target D50 and polymorph through ±0.5°C temperature accuracy, tuned supersaturation control and the low-shear HWM impeller.

Precise Temperature Ramp

TCU + jacketed tank combination delivers a cooling curve with ±0.5°C accuracy.

Low-Shear Impeller

HWM axial impeller homogenizes without breaking freshly formed crystals.

Supersaturation Control

Seeding, cooling rate and antisolvent dosing are managed via recipe through the DCS.

CFD-Validated Design

Mixing time, dead-zone analysis and temperature homogeneity are validated with CFD for every system.

Batch and Continuous

Single-reactor batch or MSMPR-configuration continuous crystallization.

GMP Option

AISI 316L + electro-polished sanitary design for pharmaceutical intermediates.

SİSTEM BİLEŞENLERİ

System Components

Main Mechanimix equipment used in the crystallization line.

UYGULAMA ALANLARI

Uygulama Alanları

Fine Chemicals

Crystallization of high-value-added organic intermediates.

Pharmaceutical Intermediates

API crystallization; polymorph control and particle size distribution.

Sugar Crystallization

Sugar refinery crystallizers in continuous and batch modes.

Salt and Minerals

Inorganic crystallization such as NaCl, KCl and sulfate salts.

TEKNİK ÖZELLİKLER

Teknik Özellikler

ÖzellikDeğer
Capacity Range0,5 – 50 m³
Design Temperature−20 … +200 °C
Temperature Accuracy±0,5 °C (TCU ile)
MaterialAISI 316L / Duplex / Hastelloy C-276
Impeller TypeHWM / HWM-B düşük kesme
Tip Speed1 – 3 m/s (kristale göre)
Process ModeBatch, fed-batch, sürekli (MSMPR)
StandardsPED 2014/68/EU, ASME VIII Div.1
NEDEN MECHANIMIX

Why Mechanimix?

Crystallization Engineering

Process design supported by solubility curve, metastable zone and cooling-rate analyses.

CFD Validation

Dead-zone and temperature homogeneity validated by CFD; CSD prediction provided.

Single-Source Responsibility

Reactor, impeller, TCU and control system — an integrated solution from a single supplier.

Pilot and Scale-Up

Safe scale-up from lab-scale DOE to industrial scale.

SIKÇA SORULAN SORULAR

Sıkça Sorulan Sorular

Which parameters affect crystal size?+
The crystal size distribution (CSD) is governed by supersaturation level, cooling rate, mixing intensity, seeding strategy and residence time. High supersaturation and fast cooling produce many small crystals (primary-nucleation dominant), whereas slow cooling and controlled seeding produce large and uniform crystals. These parameters must be optimized via DOE for the target D50.
Why does HWM deliver low shear?+
Thanks to its wide-blade, inclined axial profile, HWM delivers high pumping efficiency at a low tip speed (typically 1–2 m/s), reducing blade-tip shear by a factor of 3–5 compared to a Rushton turbine. As a result, fragile freshly formed crystals are not mechanically broken and the CSD is preserved. This advantage is especially decisive for needle- or plate-shaped crystal morphologies.
How is nucleation and growth control achieved?+
Primary nucleation is suppressed by seeding inside the metastable zone (MSZ), shifting the system to a controlled secondary nucleation + growth regime. The cooling curve follows a profile that is initially slow and then accelerated (cubic cooling) so that it never approaches the MSZ boundary. PAT tools such as FBRM or ATR-IR monitor the process in real time and keep supersaturation constant.
Why is temperature ramp control critical?+
There is a non-linear relationship between supersaturation and temperature; even a 1°C deviation can push the system outside the metastable zone and trigger unexpected primary nucleation. This disturbs the particle size distribution and can cause polymorph changes. Half-pipe jacket, high-flow TCU and cascaded PID cooling are required to achieve ±0.5°C accuracy.
What does CFD simulation add to crystallization?+
CFD analysis identifies dead zones (stagnant flow regions), temperature inhomogeneities and slurry settling risk areas within the tank at the design stage. Coupled with a Population Balance Model (PBM), it can predict CSD for different impeller types and positions. Mechanimix delivers the CFD report together with the FAT documents on every crystallization project, so commissioning runs without surprises.

Projeniz İçin Ücretsiz CFD Analizi

Proses ihtiyaçlarınıza en uygun sistem konfigürasyonu için mühendislik ekibimizle görüşün. İlk değerlendirme ve ön fizibilite ücretsizdir.

Teklif Alın