Sterile-designed, kLa-optimized, CIP/SIP-compliant and GMP-ready bioreactor systems for cell culture and microbial fermentation.
The success of a bioprocess depends on simultaneously delivering oxygen transfer rate (kLa), controlled shear on the cells, sterile barrier integrity and tight pH/DO control. Mechanimix bioreactors offer scale-up confidence from lab scale up to 50 m³ production scale with a kLa-optimized GDM/HWM impeller combination, optional bottom-entry magnetic coupling, electro-polished internal surface and full CIP/SIP capability.
High oxygen transfer efficiency through a GDM gas-distribution impeller + HWM axial impeller combination.
Impeller geometry operating at low tip speed in the laminar regime for cell culture.
Double mechanical seal + steam barrier completely eliminates contamination risk.
Spray-ball coverage and 135°C SIP capability meet FDA and GMP requirements.
DO, pH, OD, CO₂, temperature and foam sensors are connected to DCS/SCADA via a PAT framework.
Transition from 10 L pilot to 50 m³ production using kLa, P/V or tip-speed constancy strategies.
Main Mechanimix equipment used in the bioreactor and fermentation line.
AISI 316L jacketed tank for large-volume fermentation, Ra ≤ 0.5 µm.
Detaylı İncele →Pressure-rated tank for SIP and positive-pressure bioreactors.
Detaylı İncele →Low-shear, high-pumping axial impeller for cell culture.
Detaylı İncele →Hollow-blade self-inducing impeller for microbubble distribution.
Detaylı İncele →Zero-leak magnetic coupling, GMP-compliant bottom-entry drive.
Detaylı İncele →Double mechanical seal + steam barrier for aseptic production.
High-kLa bioreactors for production fermentations such as penicillin and cephalosporin.
Microbial fermentation of industrial enzymes: amylase, protease, lipase.
Yeast fermentation with CO₂ management and thermal regime at 50 m³+ scale.
Low shear, precise DO/pH control and scale-up for CHO cell culture.
| Özellik | Değer |
|---|---|
| Capacity Range | 10 L – 50 m³ |
| Material | AISI 316L / L-grade, Ra ≤ 0.5 µm elektro-polisaj |
| Design Pressure | −1 / +4 bar (SIP için) |
| Sterilization | CIP 80°C / SIP 135°C |
| Impeller Type | GDM + HWM kombinasyonu |
| Tip Speed | 0,5 – 2,5 m/s (hücreye göre) |
| kLa | 100 – 500 h⁻¹ (aplikasyona göre) |
| Standards | ASME BPE, FDA, EU GMP Annex 1 |
Scale-up calculations based on kLa, P/V or tip-speed constancy are performed by our team.
Drainability, riboflavin coverage test and dead-leg analysis are reported prior to commissioning.
Zero leakage with BED-N magnetic coupling — no contamination risk in aseptic production.
IQ/OQ protocols, FAT/SAT and material certificates delivered as a complete package.
Proses ihtiyaçlarınıza en uygun sistem konfigürasyonu için mühendislik ekibimizle görüşün. İlk değerlendirme ve ön fizibilite ücretsizdir.
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