Sterile-designed, kLa-optimized, CIP/SIP-compliant and GMP-ready bioreactor systems for cell culture and microbial fermentation.
The success of a bioprocess depends on simultaneously delivering oxygen transfer rate (kLa), controlled shear on the cells, sterile barrier integrity and tight pH/DO control. Mechanimix bioreactors offer scale-up confidence from lab scale up to 50 m³ production scale with a kLa-optimized GDM/HWM impeller combination, optional bottom-entry magnetic coupling, electro-polished internal surface and full CIP/SIP capability.
High oxygen transfer efficiency through a GDM gas-distribution impeller + HWM axial impeller combination.
Impeller geometry operating at low tip speed in the laminar regime for cell culture.
Double mechanical seal + steam barrier completely eliminates contamination risk.
Spray-ball coverage and 135°C SIP capability meet FDA and GMP requirements.
DO, pH, OD, CO₂, temperature and foam sensors are connected to DCS/SCADA via a PAT framework.
Transition from 10 L pilot to 50 m³ production using kLa, P/V or tip-speed constancy strategies.
Main Mechanimix equipment used in the bioreactor and fermentation line.
AISI 316L jacketed tank for large-volume fermentation, Ra ≤ 0.5 µm.
Detaylı İncele →Pressure-rated tank for SIP and positive-pressure bioreactors.
Detaylı İncele →Low-shear, high-pumping axial impeller for cell culture.
Detaylı İncele →Hollow-blade self-inducing impeller for microbubble distribution.
Detaylı İncele →Zero-leak magnetic coupling, GMP-compliant bottom-entry drive.
Detaylı İncele →Double mechanical seal + steam barrier for aseptic production.
High-kLa bioreactors for production fermentations such as penicillin and cephalosporin.
Microbial fermentation of industrial enzymes: amylase, protease, lipase.
Yeast fermentation with CO₂ management and thermal regime at 50 m³+ scale.
Low shear, precise DO/pH control and scale-up for CHO cell culture.
| Özellik | Değer |
|---|---|
| Capacity Range | 10 L – 50 m³ |
| Material | AISI 316L / L-grade, Ra ≤ 0.5 µm elektro-polisaj |
| Design Pressure | −1 / +4 bar (SIP için) |
| Sterilization | CIP 80°C / SIP 135°C |
| Impeller Type | GDM + HWM kombinasyonu |
| Tip Speed | 0,5 – 2,5 m/s (hücreye göre) |
| kLa | 100 – 500 h⁻¹ (aplikasyona göre) |
| Standards | ASME BPE, FDA, EU GMP Annex 1 |
Scale-up calculations based on kLa, P/V or tip-speed constancy are performed by our team.
Drainability, riboflavin coverage test and dead-leg analysis are reported prior to commissioning.
Zero leakage with BED-N magnetic coupling — no contamination risk in aseptic production.
IQ/OQ protocols, FAT/SAT and material certificates delivered as a complete package.
Consult with our engineering team for the system configuration best suited to your process needs. Our engineering team will design the system best suited to your process conditions.
Get a Quote →